PRÊMIO DE RESIDÊNCIA MÉDICA

328 Prêmio de Residência Médica randomizados são necessários para estabelecer o papel da congelação intra-operatória do linfonodo sentinela no câncer de mama em estágios iniciais, assim como para determinarmos se a omissão de esvaziamento axilar não oferece impacto na sobrevida das pacientes com câncer de mama inicial e doença linfonodal mínima. A mudança na abordagem axilar das pacientes com câncer de mama tratadas com cirurgia conservadora teve impacto positivo em reduzir as taxas de esvaziamento axilar negativo e suas sequelas nesse grupo selecionado de pacientes. REFERÊNCIAS 1. J.M. Kurtz, K. Kinkel. Breast conservation in the 21st century European Journal of Cancer 36 (2000) 1919-1924. 2. Stefano Zurrida S MD and Umberto Veronesi U. MD Milestones in Breast Cancer Treatment. The Breast Journal Volume 21 Number 1, 2015 3–12 3. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E. Twenty-year follow- up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1332. 4. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N. Twenty-year follow- up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241. 5. Fisher B, Anderson S, Bryant J, et al. Twenty-year follow- up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347(16):1233–41. 6. Krag DN, Weaver DL, Alex JC, et al. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe. Surg Oncol 1993;2:335–9. 7. Giuliano AE, Dale PS, Turner RR, et al. Improved axillary staging of breast cancer with sentinel lymphadenectomy. Ann Surg 1995;222:394–401. 8. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med 2003;349:546–53. 9. Veronesi U, Viale G, Paganelli G, et al. Sentinel lymph node biopsy in breast cancer: ten-year results of a randomized controlled study. Ann Surg 2010;251:595–600. 10. Bilimoria KY, Bentrem DJ, Hansen NM, et al. Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node- positive breast cancer. J Clin Oncol. 2009;27:2946–2953. 11. Galimberti V, Cole BF, Zurrida S, et al. Axillary dissection versus no axillary dissection in patients with sentinel-node microme- tastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lan- cet Oncol 2013;14:297–305. 12. Giuliano AE, Hunt KK, Ballman KV, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 2011;305:569–75. 13. Theriault RL1, Carlson RW, Allred C, et al. Breast cancer, version 3.2013: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2013 Jul;11(7):753- 60; quiz 761.